个人简介
张成，教授，硕导，广州医科大学药学院PI。专注于分子结构设计与合成方法研究，开发新型小环以及杂环骨架，为药物研发、生物技术提供新的支持，在相关领域发表有系列研究成果。
工作经历
| 时间 | 职位 |
|---|---|
| 2024年1月-至今 | 广州医科大学 药学院 教授 |
| 2024年1月-2024年8月 | 海德堡大学 药物与分子生物技术所 客座研究员 |
| 2021年11月-2024年1月 | 海德堡大学 药物与分子生物技术所 博士后 |
教育背景
| 时间 | 学历 |
|---|---|
| 2018年9月-2021年9月 | 海德堡大学 有机化学 博士 |
| 导师：A. Stephen K. Hashmi | |
| 2015年9月-2018年6月 | 苏州大学 化学 硕士 |
| 导师：Xinfang Xu | |
| 2011年9月-2015年6月 | 苏州大学 应用化学 本科 |
| 导师：Xinfang Xu |
研究方向
- 专注于分子结构设计与合成方法研究
- 开发新型小环以及杂环骨架
- 为药物研发、生物技术提供新的支持
论文发表
17) C. Zhang,* S. Dong, M. C. Dietl, M. Rudolph, X. Zhang, K. Hong, W. Yi, A. S. K. Hashmi,* X. Xu* Chem Catal. 5, 101163 (2025): Practical and modular cycloadditions of in-situ-formed exocyclic vinylcarbenes (11.5).
16) C. Zhang, K. Hong, S. Dong, M. Liu, M. Rudolph, M. C. Dietl, J. Yin, W. Hu, A. S. K. Hashmi,* X. Xu* ACS Catal. 13, 4646 (2023): Generation and Utility of Cyclic Dienyl Gold Carbene Intermediates (IF: 11.3).
15) C. Zhang,* Q. Chen, L. Wang, Q. Sun, M. Rudolph, F. Rominger, A. S. K. Hashmi* Sci. China Chem. 65, 1338(2022): Practical and Modular Construction of Benzo[c]phenanthridine Compounds (IF: 10.4).
14) C. Zhang, Q. Sun, M. Rudolph, F. Rominger, A. S. K. Hashmi,* ACS Catal. 11, 15203 (2021): Gold-Catalyzed Regiodivergent Annulations of Diazo-Alkynes Controlled by Et3N(HF)3 (IF: 11.3).
13) C. Zhang, K. Hong, C. Pei, S. Zhou, W. Hu, A. S. K. Hashmi,* X. Xu* Nat. Commun. 12, 1182 (2021): Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights. (IF: 14.7).
12) C. Zhang, H. Li, C. Pei, L. Qiu, W. Hu,* X. Bao,* X. Xu* ACS Catal. 9, 2440 (2019): Selective vinylogous reactivity of carbene intermediate in gold-catalyzed alkyne carbocyclization: synthesis of indenols. (IF: 11.3).
11) C. Zhang, K. Hong, S. Dong, C. Pei, X. Zhang, C. He, W. Hu,* X. Xu* iScience 21, 499 (2019): Gold(I)-catalyzed aromatization: expeditious synthesis of polyfunctionalized naphthalenes. (IF: 6.107).
10) X. Tian, L. Song, C. Han, C. Zhang, Y. Wu, M. Rudolph, F. Rominger, A. S. K. Hashmi,* Org. Lett. 21, 2937 (2019): Gold(III)-Catalyzed Formal [3 + 2] Annulations of N-Acyl Sulfilimines with Ynamides for the Synthesis of4-Aminooxazoles. (IF: 6.072).
9) C. Zhang, S. Chang, S. Dong, L. Qiu,* X. Xu* J. Org. Chem. 83, 9125 (2018): Acid-Promoted Bicyclization of Diaryl Alkynes: Synthesis of 2H-Indazoles with in Situ Generated Diazonium Salt as Nitrogen Source. (IF: 4.198).
8) C. Zhang, S. Dong, Y. Zheng, C. He, J. Chen, J. Zhen, L. Qiu,* X. Xu* Org. Biomol. Chem. 16, 688 (2018): Synthesis of Spiro-4H-Pyrazole-Oxindoles and Fused 1H-pyrazoles via Divergent, Thermally Induced Tandem Cyclization/Migration of Alkyne-Tethered Diazo Compounds. (IF: 3.890).
7) C. Pei, C. Zhang, Y. Qian, X. Xu* Org. Biomol. Chem. 16, 8677 (2018): Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization. (IF: 3.890).
6) J. Cai, B.Wu, G. Rong, C. Zhang, L. Qiu,* X. Xu* Org. Lett. 20, 2733 (2018): Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused Indole and Spirooxindole Derivatives. (IF: 6.072)
5) C. Zhang, S. Chang, L. Qiu, X. Xu* Chem. Commun. 52, 12470 (2016): Chemodivergent Synthesis of Multi-substituted/Fused Pyrroles via Copper-Catalyzed Carbene Cascade Reaction of Propargyl α-Iminodiazoacetates. (IF: 6.056).
4) C. Zhang, J. Huang, L. Qiu,* X. Xu* Org. Lett., 18, 6208 (2016): Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights. (IF: 6.072).
3) X. Wang, K. Dong, B. Yan, C. Zhang, L. Qiu, X. Xu* RSC adv. 6, 70221 (2016): NBS-mediated dinitrogen extrusion of diazoacetamides under catalyst-free conditions: practical access to 3-bromooxindole derivatives. (IF: 4.036).
2) X. Wang, Y. Zhou, L. Qiu, R. Yao, Y. Zheng, C. Zhang, X. Bao, X. Xu* Adv. Synth. Catal. 358,1571 (2016): Enantioselective Carbene Cascade: An Effective Approach to Cyclopentadienes and Applications in Diels–Alder Reactions. (IF: 5.981).
1) J. Chen, J. Mao, Y. Zheng, D. Liu, G. Rong, H. Yan, C Zhang, D Shi* Tetrahedron 71, 5059 (2015): Iodine-promoted decarboxylative C–S cross-coupling of cinnamic acids with sodium benzene sulfinates. (IF: 2.388).
专利
3）ZL201711208169.6 徐新芳，洪科苗，郑洋，张成，邱丽华 (螺环4-氢吡唑类化合物的合成方法)
2）ZL201810300237.X 徐新芳，常赛兰，洪科苗，张成，邱丽华 (多环2-氢环吡唑类化合物的合成方法)
1）ZL201810301545.4 徐新芳，苏涵，蔡菊，张成，邱丽华(螺环吲哚类化合物的合成方法)
经费
3）国家自然科学基金青年项目 2025-2027 NSFC 30万
2）“高水平大学建设项目”引进高层次人才科研启动 2024-2029 广州医科大学 300万
1）Preclinical development of antiviral protease inhibitors targeting flavi- and coronaviruses 2021-2024 Volkswagen 380万