The center pioneers innovative drug discovery approaches by integrating synthetic chemistry, computational modeling, and translational research. It is committed to developing breakthrough therapeutics for unmet medical needs through interdisciplinary collaboration.
Development of high-throughput chemical assays to measure enzyme kinetics, inhibition constants, and substrate specificity for drug target validation.
Design of fluorescence-based and SPR-based chemical assays to quantify biomolecular interactions between small molecules and target proteins.
Development of LC-MS/MS based chemical assays for sensitive quantification of endogenous metabolites in biological samples.
Optimization of cell-based assays to evaluate compound toxicity, including MTT, LDH release, and live/dead staining protocols.
Development of reporter gene and phosphorylation-based cell assays to study pathway modulation by small molecule compounds.
Integration of automated microscopy and image analysis for cell-based phenotypic screening and subcellular localization studies.